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Unformatted text preview: b 3 OH Comes from H-bonding (2x distance of covalent bond), Bases have hydrophobic interactions, with e clouds above & below plane, strengthen dbl helix 10 bp/turn, 3.4 nm/turn Most proteins bind DNA in major groove Affected by G+C content, solvent, nature of DNA Requires DNA-dependent RNA polymerase (RNA polymerase), promoter, transcription factors, nucleotide triphosphates RNA polymerase Binds to DNA promoter, melts DNA near start site to form transcription bubble/open complex, catalyzes phosphodiester bonds Polymerase reads 3-5, synthesizes 5-3 Releases RNA and dissociates from DNA...
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This note was uploaded on 09/08/2011 for the course CELL BIO & 01:146:473 taught by Professor Brewer during the Spring '11 term at Rutgers.
- Spring '11