Chapter 15 HOW GENES WORK

Chapter 15 HOW GENES WORK - GenotypetoPhenotype...

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Chapter 15  HOW GENES WORK Genotype to Phenotype Summary *History *The Genetic Code *Watson and Crick *Characteristics *How the code is used History *Mendel gave us insight on how traits or characteristics are inherited. *1903 – Sutton and Bovary published the Chromosome Theory of Inheritance: *Meiosis causes patterns of inheritance observed by Mendel *Hereditary factors are genes located on DNA. *How do genes cause certain traits to appear? *Physicians noted that certain diseases seemed to run in families. *Garrod was interested in one such disease, alcaptonuria.   *This disease is characterized by the accumulation of a substance that is  excreted in the urine, turning it black. *The accumulation of this substance is caused by an error in a metabolic  pathway.   *Metabolic pathways      are series of chemical reactions each catalyzed by a  certain enzyme (protein – coded for on DNA). *Conclusion:  a defect or lack of an enzyme causes accumulation of one of the 
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Chapter 15 HOW GENES WORK - GenotypetoPhenotype...

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