Cl_2_lecture - BIOL / BMB 460 Class 2 Developmental control...

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BIOL / BMB 460 Class 2 Developmental control of gene expression
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Some of the topics that interest you: •Stem cells •Sex determination •Human genetic disorders •Applications of developmental biology to health and medicine •Specialization of cell types
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Learning goals for class 2 Be able to: Compare information content of different genomes from genomic data. Recognize the functions of different portions of the genome. Apply the concept of combinatorial control to explain the regulation of gene expression during development.
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Genomic information Which of the following is the ideal way to compare the information contained in the respective genomes of two different kinds of organisms? A. Compare the complexity (number of DNA nucleotides in nonrepetitive sequences) in the two genomes. B. Sequence the two genomes, count the number of putative genes based on computer analysis, etc., and compare these numbers. C. Count the number of different proteins that are synthesized throughout each animal's life cycle and compare these numbers. D. Compare the non-coding regions of the genome
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Genome sizes in various phyla C. elegans
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In the genomes of more complex organisms, there is a much higher proportion of non-coding DNA than there is in the smaller genomes. What’s in the non-coding DNA? introns regulatory regions splicing enhancers and silencers transcription enhancers and silencers transposons untranslated RNAs micro RNAs “junk” (unknown function) Most relevant for us: regulatory regions
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Differential gene expression “Gene expression” :
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This document was uploaded on 09/09/2011.

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Cl_2_lecture - BIOL / BMB 460 Class 2 Developmental control...

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