Cl_3_lecture - BIOL BMB 460 Class 3 Cell-cell Signaling...

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BIOL / BMB 460 Class 3 Cell-cell Signaling
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Cell signaling is the foundation of development Learning Goals 1. Describe in general the process by which developmental signals are sent from one cell and received by other cells, and what happens in the receiving cells as a result. 2. Compare and contrast the major developmental signaling pathways (RTK,TGF- β , Wnt, Hedgehog). 3. Explain how a mutant component of a signaling pathway can cause a cell to become cancerous.
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During embryonic development, cells communicate with each other This allows cells to do different things depending on what signals they received Sometimes the changes shown at right are accomplished through cytoplasmic localization of mRNAs and proteins rather than signaling Many signaling pathways have growth factors as ligands
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Three different classes of membrane bound receptors 2 1
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Three different classes of membrane bound receptors 3
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We will talk about three general types of intercellular signaling: juxtacrine, paracrine and autocrine and Which is which? A. Paracrine Juxtacrine Autocrine B. Paracrine Autocrine Juxtacrine C. Juxtacrine Paracrine Autocrine D. Juxtacrine Autocrine Paracrine E. Autocrine Paracrine Juxtacrine
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Types of signaling pathways The vast majority of all developmental signaling events are due to 5 pathways: 1. FGF 2. TGF β 3. Wnt 4. Hedgehog 5. Notch/Delta (juxtacrine; will discuss in future!)
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