Cl_4_lecture

Cl_4_lecture - BIOL / BMB 460 Class 4 Cell fate,...

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BIOL / BMB 460 Class 4 Cell fate, determination, and commitment
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Cell fate, determination, and commitment Learning Goals 1. Diagram the two major mechanisms of cell determination and explain their general molecular basis. 2. Distinguish (experimentally) between cell fate, cell commitment, and cell differentiation. 3. Explain what cytoplasmic maternally-contributed determinants are, and justify their importance during development. 4. Describe how the extracellular matrix (ECM) is involved in signaling and cell fate determination.
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What does it mean (molecularly) when we say that a cell is “committed” to take on a particular fate? A. It can still make a different fate if given the right signals B. It is actively translating cell-specific proteins C. It can no longer respond to certain signals D. It has differentiated into its known fate
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Signaling plays a role in the most fundamental steps of development: cell fate and commitment Fate: The fate of a cell in the embryo is the cell types and tissues that it will give rise to during normal embryogenesis. Commitment: When a cell or group of cells become “determined” or committed, they are irreversibly changed at the molecular level Series of changes (progressive)
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Every cell in the body has the same genetic material ( as proven by the feasibility of cloning) BUT, during development, genes are turned on or off
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Cl_4_lecture - BIOL / BMB 460 Class 4 Cell fate,...

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