L08 Objectives

L08 Objectives - L08 Objectives 1 Growth Factors= proteins...

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L08 Objectives 1.) Growth Factors= proteins that stimulate cell growth and promote cell survival 2.) Neurotrophin= proteins that stimulate cell growth and promote cell survival EXCLUSIVELY IN NERVOUS SYSTEM 3.)Growth factors and neurotrophins elicit bio effects via stimulation of RTK’s a.)Neurotrophin=TRK 4.) Neurotrophin TRK binding ligands and their respective extracellular domain a.) NGF (nerve growth factor)=TrkA b.)NT4/5 and BDNF (brain-derived neurotrophic factor)= TrkB c.) NT3= TrkC 5.) Epidermal Growth factors= EGF (stem cells) (neuregulin) 6.) Purinergic Transmitters (considered a NT) a.) 3 major purinergic transmitters( aka nucleosides): 1.)Adenosine (activation=sedation and anxiolysis) 2.)ATP 3.) ApnA (n=# of phosphatases btw 2 adenosine molecules) 7.) Storage and release of ATP and ApnA a.) same as usual, VESICULAR b.) synaptic release is Ca2+ dependent 8.) Adenosine Release a.) NON-VESICULAR b.) membrane-bound phosphatase metabolizes ATP adenosine
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L08 Objectives - L08 Objectives 1 Growth Factors= proteins...

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