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Unformatted text preview: Psych115 Neuropharmacology Lecture 2: Review of Neurotransmission Lecture 2: Objectives • Identify the 4 major parts of a neuron. • Explain how an interneuron differs from a more conventional neuron, like a motor neuron • List the organelles in the nucleus and state each of their functions • Define “dendritic spine” and explain its role in the integration of multiple neurotransmitter inputs • Describe the mechanism through which a neurotransmitter is transported to the terminal • Define a varicosity and explain how neurotransmitter release through varicosities differs from a point-to- point synaptic contact. • Describe the different types of synapses and illustrate a “real-life” scenario when these different forms of synaptic contact interact to influence neurotransmission. • Define “active zone” and “post-synaptic density” • List the basic steps involved in vesicle docking and neurotransmitter release and describe the role for the different v- and t-SNAREs in this proces • Explain how the stable v-SNARE-t-SNARE complex is dissociated to enable the recycling of vesicles • Define the role for synapsins, complexins and synaptotagmin for neurotransmitter release • Describe the 3 major mechanisms involves in terminating a neurotransmitter signal. • Define “autoreceptor” and describe its role in regulating neurotransmitter release • Describe the distribution of ions across the neuron membrane at rest and explain how random motion, electrostatic pressure, ion permeability and active transport contribute to this distribution at rest • Describe what happens to the resting membrane potential when a neuron receives excitatory or inhibitory input • Compare and contrast “spatial summation” and “temporal summation” and explain how either or both of...
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- Spring '11
- axon hillock, neurotransmitter release, active zone, multiple neurotransmitter inputs