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Unformatted text preview: 1 Psych115 Neuropharmacology Lecture 3: Elaborating on Intracellular Signaling- PI and cAMP Lecture 3: PI signaling Describe why activation of ionotropic receptors lead to “fast” synaptic transmission, whereas the activation of other receptor super-families mediate “slow” synaptic transmission Describe the structure and function of ionotropic receptors. Describe the structure and function of metabotropic receptors. Compare and contrast the 4 general patterns of signal transduction within a neuron List the different G proteins and outline their major intracellular signaling cascades, including the kinases or lipases activated. Explain how RGS and AGS proteins regulate G protein signaling in neurons Explain how a neurotransmitter can elicit immediate, short-term and long-term effects upon cell activity List the major family of receptors, the activation of which can lead to phosphoinositide signaling List the 3 major phosphoinositides in the brain Describe the function of PI-PLC and list the 2 initial byproducts of its reaction Explain briefly how the breakdown of PIP4 can regenerate the precursor for PIP4 Provide a putative therapeutic mechanism for the anti-OCD drug Li+ (lithium) Describe the function of PI4K and PI5K and explain what might happen to PI signaling if you were to inhibit these 2 kinases Define PI3K and explain what might happen if you blocked its function Define an isozyme Describe the function of the PH domain on PLCs Explain how the structure of PLC γ enables it to interact specifically with RTKs Describe the 3 major mechanisms for the activation of PLCs Describe how activation of PLCs can lead to the stimulation of PKC-and Ca2+-dependent intracellular signaling pathways Describe the major features of the IP3 receptor and how they contribute to Ca2+ release from internal stores Describe the major functions of polyphosphate-5-phosphatases and inositol monophosphatase...
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- Spring '11
- Synaptic Transmission, major intracellular signaling