Lecture_4-Intracellular_Signaling_II-4_slides - Lecture 4...

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1 Psych115 Neuropharmacology Lecture 4: Elaborating on Intracellular Signaling- Calcium and Serine/Threonine Kinases Lecture 4: Calcium In the majority of eukaryotes, describe where Ca2+ is stored/located and explain the major force acting upon Ca2+ to cause rapid increases in internal Ca2+ levels Describe the 2 major plasma membrane transport mechanisms that determine the steady-state internal Ca2+ levels and explain how they function Explain how the ER and mitochondria contribute to the regulation of internal Ca2+ Describe the 2 major sources of Ca2+ that are involved in Ca2+ signaling Explain why the ryanodine receptor is considered to be a “pure” CICR, while the IP3 receptor is not Describe the 2 major sources of Ca2+ entry from the extracellular fluid into the cell and compare how they differ in terms of their modes of activation Lecture 4: Ser/Thr and Tyr Kinases Compare and contrast protein kinases and protein phosphatases in terms of their general function Compare and contrast the 3 major types of protein kinases in terms of their function Explain how kinases can lead to changes in protein function Describe the general schema through which the activation of G-protein-coupled receptors and tyrosine kinase receptors can lead to cell signaling through phosphorylation Define AKAPs and RACKs explain their roles in PKA and PKC function Review the activation of PKA, PKG and PKC and explain how the activation of these kinases differs/is similar to the activation of CaMKs Describe how MAPKs differ from the 2 nd messenger-dependent kinases in terms of their activation Outline the ERK pathway in detail Describe how the activation of GRKs can lead to receptor desensitization Compare and contrast the function of Ser/Thr kinases and PTKs Define “small G protein” and describe their activation, regulation and major function Compare and contrast RTKs and NRTKs in terms of their activation and subcellular localization Explain the general scheme of how ligand binding leads to activation of RTKs Explain how the activation of RTKs and recruitment of SH2-containing proteins can lead to the activation of DAG/IP3 and MAPK pathways Explain how the different SH domains of Src contribute to its function and localization Describe the factors that can influence NRTK activity Describe the structure and functional aspects of RTKs Compare and contrast protein Ser/Thr and protein Tyr phosphatases Describe how a phosphatase inhibitor like DARPP-32 influences receptor signaling Define a SHP and explain how the 2 major SHPs can affect RTK activity Describe the major structural features of RTPs Lecture 4: Transcription Describe the features of DNA that enable it to serve in information storage and transfer Define nucleotide and codon and explain how the DNA sequence dictates the amino acid content of a protein Compare and contrast mRNA, rRNA, tRNA in terms of structure, function and cellular localization
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Lecture_4-Intracellular_Signaling_II-4_slides - Lecture 4...

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