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Lecture_5-Neuropeptides_and_Hormones-1_slide

Lecture_5-Neuropeptides_and_Hormones-1_slide - Lecture 5...

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Lecture 5: Neuropeptides and Hormones
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Lecture 5: Objectives-Neuropeptides Define “peptide” and contrast with “neuropeptide” Compare and contrast the synthesis, storage and release of neuropeptides with those of the classical neurotransmitters (e.g., dopamine or serotonin; will see next lecture) Describe how N terminal acetylation and C-terminal modifications can affect the activity of the neuropeptide Describe the difficulties faced by neuropeptide pharmacologists regarding the design of selective agonists and antagonists for neuropeptide receptors Discriminate between opiates and opioids Compare and contrast the three main classes of opioid peptides in terms of their precursors, and receptor preferences Describe the major intracellular signaling pathway used by opioid receptors Describe the mechanisms of action of morphine, heroin, oxycodone, codeine, naloxone and naltrexone and explain how these drugs impact addiction by affecting dopamine transmission within the nucleus accumbens Explain how by affecting dopamine release in the nucleus accumbens, kappa agonists might lead to dysphoria
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Peptide Neurotransmitters or Neuropeptides -small proteins, made up of the 20 amino acids; joined by peptide bonds -neuropeptide: peptides that serve as neurotransmitters; can also serve as hormones
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