Lecture_6-Monoamines-4_slides

Lecture_6-Monoamines-4_slides - Lecture 6: Catecholamine...

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1 Psych 115 Lecture 6: Monoamines Lecture 6: Catecholamine Objectives List the 3 catecholamine neurotransmitters in our brain and describe the hallmark chemical features of catecholamine neurotransmitters Outline the synthetic pathway for dopamine, norepinephrine and epinephrine, including all enzymes involved in synthesis Explain why an increase in dietary tyrosine does not result in more catecholamine synthesis but the administration of L-DOPA can Point out which enzyme is the rate limiting step in catecholamine synthesis and describe the means through which this enzyme is regulated in the short- and long-term Describe how DA and NE are packaged into vesicles and explain how reserpine affects neurotransmitter levels Define varicosities and explain how release of catecholamines from terminals differs from amino acid neurotransmitters Compare and contrast the mechanisms of action of cocaine and amphetamine vis-à-vis the catecholamine transporters Describe the steps involved in terminating catecholamine signaling in brain, starting from the synapse Compare and contrast MAO-A and MAO-B, highlighting major inhibitors Explain how genetic variance in COMT might affect DA and NE levels within the prefrontal cortex Describe the origins and projections of the major DA and NE pathways in the brain Describe the classification of DA receptors into D1-like and D2-like families based on intracellular signaling cascades Describe the classification of adrenergic receptors based on intracellular signaling cascades Understand how DA receptors are classified and know the biochemical function of the major classes Understand distinction between postsynaptic and autoreceptors, as well as their function Know basics of drug action at DA receptors, including major classes of abused and therapeutic drugs Understand clearance of DA from synapse as well as the enzymatic deactivation of the neurotransmitter Lecture 6: Objectives Describe the role for D2/D3 and alpha2 receptors in regulating neurotransmitter release Distinguish between D1 and D2 receptors in terms of their cellular localization Describe the pathway for DA or NE receptor internalization upon stimulation Review the steps involved in DA and NE synthesis, storage, release, receptor activation, reuptake and degradation NE Origins: Pons and medulla A6/A4: Locus coeruleus + caudal extension A5/A7: Lateral tegmental area A2: dorsal medullary group DA A10: substantia nigra pars compacta A9: ventral tegmental area Arcuate nucleus (hypothalamus) Relatively discrete projections of the major catecholamine pathways in the brain
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2 What are catecholamines? Molecules with a catechol nucleus and an ethylamine group
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Lecture_6-Monoamines-4_slides - Lecture 6: Catecholamine...

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