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Study Guide Psy 115 L03 Objectives

Study Guide Psy 115 L03 Objectives - S tudy Guide Psy 115...

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Study Guide Psy 115 L03 Objectives UNANSWERED OBJECTIVES: EPSP=depolarization=rush of cations (Na+,K+,Ca2+) into cell IPSP=hyperpolarization=rush of anions (Cl-) into cell 1.) Fast synaptic transmission=ionotropic receptors or LIGAND GATED CHANNELS i. MUST HAVE 2 ALPHA SUBUNITS, USUALLY 5 SUBUNITS TOTAL, KEY AND LOCK DESIGN, DIRECTLY LINKED WITH ION CHANNELS CUZ OPENS OR CLOSES THEM AND THIS IS WHY IT IS FAST b. Slow synaptic transmission= G-protein coupled or metabotropic receptors i. INDIRECTLY LINKED WITH ION CHANNELS, MUST USE SIGNAL TRANSDUCTION MECHANISMS (G-PROTEINS, KINASES, etc.) and HAVE 2 nd MESSENGER PROTEINS ASSIST. THIS IS WHY IT IS CALLED SLOW SYNAPTIC TRANSMISSION ii. 7 hydrophobic transmembrane domains iii. N terminus on inside (intracellular), C terminus on outside(extracellular) 2.) 4 general patterns of signal transduction (communication btw cells) within a neuron a. 1.)Direct ionophore (ion transporter across lipid bilayer) activation : ion influx or efflux (NO NEED FOR 2 nd MESSENGER ION MOVEMENT IN OR OUT CELL) b. 2.)GPCR activation: indirect activation/inhibition of ionophores =stimulation of 2 nd messenger systems (protein kinases and phosphatases) (2 ND MESSENGER ION MOVEMENT IN OR OUT CELL)
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c. 3.)Neurotrophic receptor activation : activation of tyrosine kinase activity ( PHOSPHORYLATION FROM KINASE) d. 4.) Steroid receptor activation: translocation to nucleus and activation of gene transcription (DNA TRANSCRIPTION) 3.) 3 Major types of G proteins: a.
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