Study guide psy 115 neuropharm L04

Study guide psy 115 neuropharm L04 - Study guide psy 115...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Study guide psy 115 neuropharm L04 Objectives 1.) 2 major plasma membrane transport mechanisms that determine steady-state internal Ca2+ levels and how function a. 1.) Ca 2+ ATPase ( from ATP ADP) pump = enables efflux (leaving the cell) of Ca2+ against its concentration gradient b. 2.) Na+ Ca2+ exchanger= found only in excitable cells (such as neurons and muscle) drives Ca2+ out of cell and takes Na+ along its concentration gradient. Trades Na+ which wants to go in cell for Ca2+ which does NOT want to leave cell but since the + from Na is going out, concentration gradient is not as unequal. 2.) Mitochondria and its role in Ca2+ of the ER a. Energy is derived from the membrane potential across mitochondrial membrane i. This reflects H+ gradients in the electron transport chain 1. THEREFORE: if a drug interferes with H+ mitochondrial pumps, it will PREVENT Ca2+ uptake ii. Equally trades 2H+ or 2Na+ for 1 Ca2+ THEREFORE: kinectics slower than PM or ER systems 3.) Ryanodine receptors a. Ca2+ is ligand for receptor and it releases Ca2+=”calcium-induced calcium
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 09/09/2011 for the course PSY 115 taught by Professor Staff during the Spring '11 term at UCSB.

Page1 / 3

Study guide psy 115 neuropharm L04 - Study guide psy 115...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online