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Study Guide Psy 115 Neuropharmacology LECTURE 1

Study Guide Psy 115 Neuropharmacology LECTURE 1 - S tudy...

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Study Guide Psy 115 Neuropharmacology OBJECTIVES Answers Lecture 01 1.) Define: Pharmacodynamics: What drugs do to your body 2.) Define: Site of Action (receptor): parts of body where a drug acts to initiate a chain of events leading to effect 3.) Define: Mechanism of Action: Means by which drug produces an alteration in function (of anatomical structure) AT THE SITE OF ACTION 4.) Define: Receptor: (a site of action for drugs,) tissue element with which drugs act to produce a characteristic biological effect 5.) Define: Ehrlich’s receptor theory of drug action: Drugs only produce effect when they fit in receptor at site of action (think key and lock design) 6.) 4 forces involved in drug-receptor interactions: ALL CHEMICAL BONDS a. 1.) Ionic bonds: electrostatic attraction; transfer of electrons, relatively strong across D
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b. 2.) Covalent bonds: sharing of a pair of electrons, ( APROX 20x’s STRONGER THAN IONIC BOND) accounts for stability of most organic molecules ex.) CARBON BONDS c. 3.) Hydrogen Bonds: ionic bond with hydrogen, WEAK BUT STRONG W/ HIGH BOND #s d. 4.) Van der Waals Forces: very small dipoles, WEAK 7.) When a drug comes close to a receptor: a. IONIC BONDS bring drug close to receptor and electrostatic attraction holds the drug to the receptor b. HYDROGEN BONDS next step in drug binding, c. VAN der waals forces last step in drug binding 8.) Define: Dose: the amount of drug needed at a given time to produce a particular biological response. Amount of drug needed to achieve a particular concentration of drug at site of action. CONCENTRATION OF DRUG DEPENDS ON: 1.) dose 2.)TIME ------DOSAGE IS NOT ACCURACTE FOR CONCENTRATION OF DRUG AT SITE OF ACTION BECAUSE
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DOES NOT FACTOR IN TIME (to get drug to and from the site of action) 9.) IMPORTANT: THE DEGREE OF A DRUG EFFECT=FUNCTION OF QUANTITY OF THE DRUG TAKEN 10.) Law of mass action to drug receptor binding:
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