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3._Senescence_Slides

3._Senescence_Slides - Together We Will Live Forever Clint...

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8/4/2010 1 Together We Will Live Forever, Clint Mansell Put away your things Close your eyes Embrace physical pain as a helpful and essential part of life Pain and pleasure carried out by separate yet interacting systems Verifying the subjective experience of pain in others is still beyond the reach of science; leads to decisions under uncertainty Physical and emotional pain are separable, suggesting a powerful way of relating to pain to reduce suffering
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8/4/2010 2 Life expectancy has more than doubled over the last few centuries United States ( 74 ), Japan ( 83 ), Swaziland ( 32 ) Credited largely to an improvement of public health - Fewer birth related deaths - Less infectious disease - Improved nutrition Just as mountains of solid rock, Massive, reaching to the sky, Might draw together from all sides, Crushing all in the four quarters So aging and death come Rolling over living beings - Siddhartha Gautama But why?
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8/4/2010 3 Senescence (n) The process of bodily deterioration that occurs at later ages Not the same thing as aging Diverse bodily systems deteriorate at similar rates Old age is not a cause of death Intricate organization constantly damaged, but usually we are able to repair it - Structural damage (e.g. broken leg that never heals right) Senescence results from slow accumulation of wear and tear which cannot be adequately repaired - Damage to repair systems - Biochemical damage (e.g. DNA damage) - Tissue damage (e.g. atherosclerosis) Caused by normal metabolic activities and environmental factors - Converting food into ATP - UV light - Radiation - Viral infection -1,000 100,000 lesions per cell/day - This is only .0002% of genome - Interferes with proper functioning of DNA and with DNA replication
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