Fat Soluble Vitamins

Fat Soluble Vitamins - FatSolubleVitamins: Vitamins...

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Fat Soluble Vitamins: Vitamins Forms Functions Conversion Found Deficiency Toxicity Vit. A- Retinol Retinol, retinal & retinoic  acid Retinyl esters (transport in  blood) Beta Carotene Vision : Cis retinal acts as cofactor of  protein opsin to form rhodoposin (a  photoreceptor used in cell membrane  of rods/cones in eye) Reproduction DO NOT taking during pregnancy or  become pregnant up to 3 years after   treatment  (spontaneous abortions/  malformatons); cannot give blood for  up to 3 years Retinal and retinol  are readily  interconverted;  most dietary  β   carotene Yellow,  dark  green  veggie s,  carrots Rare Sx: blindness, lesions  on corneal surface,  derm. Problems Tx: Supp. Better diet Acute: n/v, vertigo,  blurry vision Chronic: problems  talking, hair loss,  hyperlipidemia,  hepatotoxicity, bone/ muscle pain, vision  issues Vit. D-  Cholecalciferol (Cholesterol  derivative) Calcitriol: active Cholecalciferol:  provitamin Bone and calcium regulation Cholecalciferol  (previtamin)  converted to  calcitriol (active) in  kidney ** plants  animal  flesh;  sunligh t Increased in statin   users Interferes with serum 
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Fat Soluble Vitamins - FatSolubleVitamins: Vitamins...

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