Lecture 01 - Introduction

Lecture 01 - Introduction - L ecture 01 Introduction The...

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Lecture 01 – Introduction The endocrine system operates in concert with the nervous system to regulate organ/tissue function - Nervous system  endocrine system regulated organ or tissue  nervous system - Endocrine system acts in a collaboration w/ nervous systems to enable specialized tissues to function in integrated fashion o Nervous system transmits electrochemical signals (2 way traffic) brain and peripheral o Endocrine release chemical mediators (hormones) into circulations for actions Major regulatory functions of the endocrine system - Hormones o Regulate reproduction, growth and development, energy production utilization and storage, immunity, maintenance of - Main function EVERYTHING! Major hormone producing tissue - Key hormones producing tissues (going from - Hypothalamus o (Key region of the brain, key place for integration for the signaling) - Pituitary gland o (master of endocrine gland) - Thyroid gland o (within it are the parathyroid glands) - Parathyroid - Adrenal glands o (cortex, key tissue to producing steroids - pancreas o (islet cells) - ovaris/test - adipose o (depot for storage and produces a number Endocrine Gland Hormones Function Pituitary, Anterior ACTH Adrenal Control FSH Gonad Regulation GH Growth Stimulation LH Gonad Regulation Prolactin Breast Milk Production TSH Thyroid Control Pituitary, Posterior ADH Water Conservation Oxytocin Uterus Contraction and Breast Milk Excretion Thyroid Thyroxine Metabolic Rate Control Parathyroid PTH Calcium metabolism Gut Gut Hormones Food Digestion Pancreas Insulin Glucose Metabolism Glucagon Adrenals Cortisol Body Preservation Aldosterone Salt Conservation Epinephrine Stress Response Ovaries Estradiol Female Characteristics Progesterone Testes Testosterone Male Characteristsics Adipose Tissue Leptin Energy Homeostasis Endocrine, paracrine, autocrine, intracine singaling - How does endocrine different from the other three o These are molecules that act as messengers o A molecule that is produced by a cell (produced by other part of the circulation, and act on distant cell/tissue) Produced by a cell enter circulation act on distant tissue i.e. growth hormone- - Paracrine o Other molecules may have similar mechanism but they are produced by a cell that act on neighboring cells (paracrine) -- - Autocrine o Produced by the cell and activates that cell
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 01 - Introduction - L ecture 01 Introduction The...

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