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Unformatted text preview: of mito) o malate/a-ketoglutarate o glutamate/aspartate o Pyruvate -Specific shuttles are required to transport most molecules across the inner mitochondrial membrane.-Mito transporters-Inner mito membrane permeability barrier o The pyruvate has transporter so its fine, but we need to get the NADH into the mito to keep the glycolysis to keep going o Specific shuttles are required to transport reducing equivalents across inner membrane Glycerol-Phosphate Shuttle (for NADH & FADH2)-3-Phospho glycerol dehydrogenase (cytoplasm)-Phosphor glycerol dehydrogenase (flavoprotein dehydro mitochondrial membrane)-NADH (cyto) FADH 2 (mito) o Allow FAD to go into electron transport chain-The phosphoglycerol is the one that transfer the FADH2 electron tranaport chain-NADH (cty) ~ FADH2 (mito) 2 ATP **better yield with shunting! Gluconeogenesis:-There are 4 new enzymes Regulators...
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.
- Spring '11