Lecture 12 - Vitamin Function in Metabolism

Lecture 12 - Vitamin Function in Metabolism - Lecture 12...

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Lecture 12 – Vitamin Function in Metabolism Vitamin: the family tree Water – soluble Fat soluble Non-B-complex B-complex Vit A (Retinol, Beta-carotenes) Absorbic acid (Vit C) Energy-releasing Hematopoietic Others Vit D (cholecalciferol) Thiamine (B1) Folic Acid Pvridoxine (B6) Vit K (phylloquinones; manquinones) Riboflavin (B2) Vitamin B12 Vit E (tocopherols Niacin (B3) Biotin Pantothenic acid (B5) Vitamin Functions MOA Deficiency Toxicity Vitamin A – Retinol Forms: Retinol, retinal (readily interconverted) Retinoic acid Retinyl esters - Transport in blood Beta carotene (retinol from beta) - Most dietary vitamin A comes in form of beta- carotene o 1 carotene = 2 retinal o INEFFICIENT CONVERSION o Less toxic than retinol o Safer form o Found in yellow & dark green veggies, carrots Vision - All trans retinal - 11-cis-retinal - Growth and wound healing - Especially epithelium Reproduction - Cis-retinal acts as cofactor of the protein opsin to form rhodopsin o functions in a similar way in rods & cones. - Rhodopsin (photoreceptor) and transducin are embedded in the cell membrane of the outer rod segment o When photon of light hits rhodopsin, it causes the isomerization of cis- retinal to trans-retinal
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 12 - Vitamin Function in Metabolism - Lecture 12...

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