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Unformatted text preview: Lecture 15 - Complex Lipid Metabolism and Physiological Functioning Type of biological lipids- Lipids derived from ketoacyl units (molecules that are not water soluble) o Fatty acids (inc. Prostaglandins and wax esters derived fro acetyl CoA) The only simple lipid o Glycerolipids o Glycerophospholipids o Sphingolipids o Saccharolipids o Polyketides- Lipids derived from isoprene units o Sterols o Prenols (inc. terpenes and Fat Soluble Vitamins)- Mixtures o Lipoproteins Defintions Glycerophospholipid- an amphipathic lipid in which two fatty acyl groups are attached to a glycerol-3-phosphate whose phosphate group is linked to a polar group Phosphatidic acid- the simplest glycerophospholipid -the precursor to other phospholipids and to triacylglycerols .- Diacylglycerol-3-phosphate. Triacylglycerol- a lipid in which three fatty acids are esterified by a glycerol backbone. - Major form of energy storage in humans. Also called a triglyceride. Cardiolipin- First isolated from heart tissue- Many autoimmune diseases, such as lupus, are associated with anti-cardiolipin antibodies for unknown reasons- Formed by the condensation of two molecules of PG with the elimination of one molecule of glycerol- Essential for oxidative phosphorylation and found mainly in the mitochondria and it activates the enzymes for the...
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- Spring '11