Lecture 20 - Pituitary and growth hormone

Lecture 20 - Pituitary and growth hormone - Lecture 20...

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Lecture 20 – Pituitary and growth hormone - - can result in acromegaly and gigantism Hypothalamus and Pituitary - Pituitary function depends on the hypothalamus, and the anatomical organization of the hypothalamus-pituitary unit reflects this relationship. - The pituitary gland lies in a pocket of bone at the base of the brain, just below the hypothalamus to which it is connected by a stalk containing nerve fibers and blood vessels. - The pituitary is composed to two lobes-- anterior and posterior - ** a pitch in the stalk can result in peripheral vision (even before hormonal problems) o Suppresses the optical chiasm Posterior Pituitary: Neuro hypophysis - Neuro because it has nerve fibers (so pituitary damage will not necessary result in less hormone because hormone is released in the hypothalamus also - Posterior pituitary : an outgrowth of the hypothalamus composed of neural tissue. - Hypothalamic neurons pass through the neural stalk and end in the posterior pituitary. - The upper portion of the neural stalk extends into the hypothalamus and is called the median eminence . Secretion of Posterior Pituitary Hormone - Hormones made in hypothalamus and released in the posterior pituitary Regulation of hypothalamus - fasting, hunger - hypothalamus can sense low leptin levels and it will change hormone in such a way so that it can respond to the starvation - it also responds to heart regulation, water balance - response = make hormone and release in posterior PR make hormone in the anterior pit. Anterior pituitary: Adenophypophysis - Anterior pituitary : connected to the hypothalamus by the superior hypophyseal artery. - is an amalgam of hormone-producing glandular cells. - produces six peptide hormones: o prolactin (PRL) o growth hormone (GH ) o thyroid stimulating hormone (TSH) o adrenocorticotropic hormone (ACTH) o follicle-stimulating hormone (FSH) o luteinizing hormone (LH). - **know the six hormones Hypothalamus and ant. Pit - Neurosecretory cells secrete releasing factors into capillaries of the pituitary portal system which are then transported to the anterior pituitary gland to regulate the secretion of pituitary hormones. -
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 20 - Pituitary and growth hormone - Lecture 20...

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