Lecture 23 _ Adrenal

Lecture 23 _ Adrenal - Lecture 23 Adrenal Question: This...

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Lecture 23 – Adrenal Question: This patient, on the left, brings in an old photo (from about 3 years ago), seen on the right. He also complains that he bruises easily and has gained a lot of fat on his belly and between his shoulders. His memory is not quite as good as it was a few years ago. The primary reason for all this is likely: A. He has aged and recently become sunburnt. B. His adrenal(s) are overproducing one or more steroid hormones. C. His adrenal glands are underactive. D. His pituitary is failing to make ACTH. The adrenal glands and adrenal hormone - Important for flight or fight response - Adrenal cortex hormones precursor: cholesterol - Adrenal medulla hormones precurose: L-tyrosine - 80 to 90% of cortisol: protein-bound - ~75 % bound to: Cortisol-binding globulin/ CBG/ transcortin - ~10-15% bound to: albumin - Zones of the Adrenal cortex o Capsule o Zona Glomerulosa (salt – ALDO) o Zona fasciculate (sugar – glucocorticoids) Cortisol and DHEA o Zona reticularis (sex) DHEA sex hormones o Medulla (inside) [catacholamines] *the zones are better at making certain enzymes - Blood flow Capsule (outside) inside o By the time it reaches the medulla there is hormone reach blood o
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 23 _ Adrenal - Lecture 23 Adrenal Question: This...

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