Quiz 02 - 1 of 20 1. Thiamine pyrophosphate is a cofactor...

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1 of 20 1. Thiamine pyrophosphate is a cofactor utilized in which of the following types of reactions? A. Carboxylation reactions. B. Decarboxylation reactions C. Phosphorylation reactions D. Transamination reactions Question 2 of 20 2. Atorvastatin (LipitorR) is a competitive inhibitor of HMG CoA reductase. This drug would be expected to increase which of the following activities in a hepatocyte? A. Activation of LXR/RXR. B. Bile acid synthesis. C. LDL receptor degradation (via Indol) D. Release of active SREBP. Question 3 of 20 3. A patient has a genetic deficiency in lipoprotein lipase. One hour after a large fatty meal, which of the following complexes or lipoproteins would be grossly elevated in this patient? A. Albumin-fatty acid complexes B. Chylomicrons C. Intermediate-density lipoproteins D. Low-density lipoproteins E. High-density lipoproteins Question 4 of 20 4. One of the major indicators of apoptosis is the increased level of phosphatidylserine in the outer leaflet of the mammalian cell membrane. Which of the following best describes the original synthesis phosphatidylserine? A. Activation of diacylglycerol by CTP followed by addition of serine. B. Activation of serine by CTP followed by addition to diacylglycerol. C. Head group exchange between serine and phosphatidylethanolamine. D. Three successive methylations of phosphatidylethanolamine. Question 5 of 20 5. You are an attending physician in the Emergency Department of a large metropolitan hospital. A 35-year old homeless man stumbles into the waiting room with a friend. He is severely ataxic (staggering gait), has opthalmoplegia (poor eye movement) and is confused and disoriented. A breathalyzer test for alcohol is negative, and a blood test shows his blood glucose to be 40 mg/dl (normal = 60-100). Your resident wants to give him IV glucose. You say, “Not yet. First we need to give him….”: A. Niacin B. B12 C. Biotin D. Thiamine Question 6 of 20 6. The 35-year old patient described in the preceding question is suffering from: A. Pellagra B. Scurvy C. Wernicke-Korsakoff Syndrome D. Pernicious Anemia Question 7 of 20 7. A ten-day old boy with severely elevated blood ammonia and elevated urine orotic acid dies in the hospital after six days of coma and cerebral edema. Both of his parents are healthy. Two years later, his mother is pregnant with a female fetus and comes for advice three
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This note was uploaded on 09/14/2011 for the course PHARM ERM taught by Professor Staff during the Spring '11 term at UCSD.

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Quiz 02 - 1 of 20 1. Thiamine pyrophosphate is a cofactor...

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