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Hematology - L ymphoid M yeloid(I mmatu re Acute...

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Lymphoid Myeloid ( Immature ) Acute leukemia (ALL) Children At this stage (the acute – does not give you big spleens) t(9:22) BCR /ABL (in both CML/ALL) Treat CNS ( immature ) Acute leukemia (AML) >20% blasts At this stage (the acute – does not give you big spleens) B-cell (more common) I MMATURE - >20 T-cell IMMATU RE - >20% AML -NDS M0 M1 M2 M4 – monocytic differentition M5 M6 - erthyroids M7- megacaryoctic Secondary MDS Recurrent cytogenetic abnormal - T(8,21) - T(16;16) - Inv16 - T(15,17) **THERAPY** o Acute Promyelocytic Leukemia (APL) treat with ATRA o APL DIC!! (once you start the ATRa they get out of the DIC) **these common ones have better prognosis Mature neoplasm Adult /elderly Mature or chronic leukemia (same as neoplasm) <20% blasts B-cell Lymphoma/leukemia T-cell Lymphoma/le ukemia MPN/MPD Adult Elderly No dysplasia Splenomegaly Increase count (cytosis) - RBC MDS Adults Elderly Dysplasia Decrease (penia) Usually no splenomegaly - Neutrophils: 1-2 lobes - Chronic lymphocytic leukemia CLL (blood/bone) -
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