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CBCmarrowExam

CBCmarrowExam - Clinical Laboratory Hematology H Elizabeth...

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H. Elizabeth Broome, M.D. UCSD Medical Center Clinical Laboratory Hematology Automated complete blood counts (CBC) Automated and manual leukocyte differential (Diff) Marrow examination Smears Tissue biopsy and clot
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Validation of CBC Blood counts often critical for diagnosis Automated counts are accurate and reliable, but they have limitations Medical technologists and physicians validate automated blood counts by: Comparing with previous results Determining if they are physiologically possible Correlate with scatterplots, histograms, blood smears, and clinical history
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Physiologic variation physiologic variation due to age, sex, altitude, pregnancy, time of day, posture Hgb and cell counts are highest in the morning, lowest in the evening with a mean difference of 8-9% Cell counts increase several % upon standing from a recumbent position
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Normal Values
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Typical Automated Cell Counter Operation Sample is aspirated and split into three segments to measure: White blood count (WBC) and differential after lysis of red cells Hemoglobin by spectrophotometry Red blood cell (RBC) and platelet (PLT) counts Two basic mechanisms to identify different cells: optical (flow cytometry) and impedance
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WBC and Differential by Optical/ Flow Cytometry
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WBC and Sizing by Optical WBC and Sizing by Optical Measurements Measurements Insert Fig 3.4 from CellDyn manual
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Complexity” Measurement by
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CBCmarrowExam - Clinical Laboratory Hematology H Elizabeth...

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