Lecture 09 - Anticoagulant and Fibrinolytic Drugs

Lecture 09 - Anticoagulant and Fibrinolytic Drugs - Lecture...

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Lecture 09 - Anticoagulant and Fibrinolytic Drugs H e p a r i n s Unfractionated (UFH) Binding to Antithrombin - Don’t work by themselves – require antithrobin - It wraps around antithrombin and target - Inhibit factor Xa Low Molecular Wt. (LMWH) Binding to Antithrombin - Don’t work by themselves – require antithrobin - It wraps around antithrombin - Inhibit factor Xa good at doing this (the shorter it is the better at this it is) - BA goes up LMWH, complicated PK – two compartment models - Depend on renal excretion Fondaparinux - Used when you suspected Heparin induced T (HIT)
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V i t . K A n t a g o n i s t s Warfarin - Inhibits Vitamin K-dependent γ -carboxylation o VKORC1 = Vit K epoxide reductase complex 1 o GGCX = gamma-glutamyl carboxylase - It blocks the carboxyl on the factors - Blocks-- Substrates : o Prothrombin o FVII o FIX o FX o Prot C o Prot S Clearance Rate of Vitamin K Dependent Factors ** - FVII shortest half life start giving warfarin VII and protein C comes down - No matter how much wafarin you need --> in 5 days when prothrombin drops 50% ten
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Lecture 09 - Anticoagulant and Fibrinolytic Drugs - Lecture...

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