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Unformatted text preview: Lecture 14 Lymphoid Tissue cell death B-cell maturation in lymph nodes, MALT, spleen-- The b cells go in primary and initially has antibody, but wants to differentiate these immunoglobulin o Naive b cells started maturation and are not complete mature o B cells go through the genital centers SHM SHM = gene goes through mutation and the mutation give them a chance to be more specific --> instead of binding to the antigen more tightly compared to loose o The type/class of antibody will matter Mucosal in GI --> igA If other tissues --> most of the time IgG o *** Switch the class igM --> to igA or igG- most of the time this process will go wrong- those that survival --> memory cells - if they were to die off --> then die off apoptosis --> since its membrane bound --> macrophages will eat it Lymphoid Maturation B-cell maturation Review: Bone Marrow (early B cells start here) Lymph Node- B cells cross the lymph nodes- Expcress CD19 and TcT as early marker- Mature with CD19 and...
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This note was uploaded on 09/14/2011 for the course PHARM HEM taught by Professor Staff during the Spring '11 term at UCSD.
- Spring '11