Lecture 15 - Acute Chronic inflammation

Lecture 15 - Acute Chronic inflammation - Lecture 15...

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Lecture 15 – Acute/Chronic Inflammation Mediators of Inflammation Mediator Source Principle Actions Cell-Derived Histamine Mast cells *(not just histamines) Basophiles Platelets Vasodilation Increase vascular permeability Endothelial activation Serotonin Platelets Vasodilation Increase vascular permeability Prostaglandins Mast Cell Leukocytes Vasodilation Pain** Fever** Leukotrienes C4, D4, E4 Mast Cell Leukocytes Increase vascular permeability Chemotaxis L eukocyte adhesion and activation (B4) Platelet-activating factor Leukocytes Endothelial cells Vasodilation Increase vascular permeability Leukocytes adhesion Chemotaxis Degranulation Oxidative burse Reactive oxygen species Leukocytes Killing of microbes Tissue damage Nitric oxide Endothelium Vascular smooth muscle relaxation
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Macrophages Killing of microbes Cytokines (TNF, IL-1) Marocphages Lymphocytes Endothelial cells Mast cells Local endothelial activation (expression of adhesion molecules) Systemic acute-phase response Leukocyte recruitment and activation Fever** Chemokines Leukocytes Activated macrophages Chemotaxis Leukocyte activation Plasma protein-derived Complement C3a and C5a Plasma (Liver) Leukocyte chemotaxis and activation Opsonization Vasodilation (mast cell stimulation) Increase vascular permeability Kinins ( Bradykinin ) Plasma (Liver) Increase vascular permeability Smooth muscle contraction Vasodilation Pain** Proteases activated during coagulation Plasma (Liver) Endothelial activation Leukocyte recruitment Eicosanoids mediate many steps of inflammation (Thromboxane A2, leukotriene, LTB4, Prostaglandins Drugs that inhibit this will reduce inflammation block off COX (NSAIDS or Indomethacin inhibitors)/phospholipases (steroids) mediators of PG and TX
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What are the main steps of an inflammatory response THE 5 R’s Recognition of the agent or injury Recruitment of leukocytes to site Removal of agent Regulation (control) of the response) Resolution (repair)
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This note was uploaded on 09/14/2011 for the course PHARM HEM taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 15 - Acute Chronic inflammation - Lecture 15...

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