Rashidi_Review

Rashidi_Review - Hematology review Hooman H. Rashidi MD...

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Hematology review Hooman H. Rashidi MD UCSD School of Medicine
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Normal Coagulation
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Anti-Coagulation Pathways
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Normal RBC Size: ~6-8 um Shape: Relatively Round Eosinophilic cytoplasm with central pallor (~1/3 of the diameter)
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Microcytic RBC (MCV <80)
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Microcytic RBC (MCV <80) Differential diagnosis: TICS: Thalassemia Iron Def. Chronic disease (sometimes) Sideroblastic anemia
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Macrocytic RBC (MCV >100)
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Macrocytic RBC (MCV >100) Differential diagnosis: Vit B12 def Folate def Chemotherapy Liver disease (e.g. alcoholism) MDS & other hematologic malignancies Thyroid disease (hypo & hyper)
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Hypersegmented Neutrophil DDx: Most commonly due to B12 or Folate deficiency
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Schistocyte
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DDx of Schistocytes (Intravascular Hemolysis) DIC TTP HUS (or Uremia) Burns Mechanical Valve induced Etc.
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Spherocyte (Extravascular Hemolysis)
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DDx of spherocytes Extravascular hemolysis AIHA MAHA (e.g. DIC) can have an extravascular hemolytic component as well being intravascular Hereditary spherocytosis Burns
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Target Cell
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Target Cell Differential diagnosis: Thalassemia HbSC, HbC Post-splenectomy Liver disease Artifact
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Sickle cell
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Hemoglobin C Crystal
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Hemoglobin C Crystal Differential diagnosis: Hb CC disease SC disease
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Hemoglobinopathies HbSS : Beta Glu Val (Hydrophilic to Hydrophobic) Hence more dramatic RBC shape changes (Sickle cells) HbCC: Beta Glu Lys (Hydrophilic to Hydrophilic) Hence RBC shape changes are less dramatic
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Reactive Lymphocytes: Increased numbers think about viral infections (e.g. EBV leading to Infectious Mono)
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Blast
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This note was uploaded on 09/14/2011 for the course PHARM HEM taught by Professor Staff during the Spring '11 term at UCSD.

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Rashidi_Review - Hematology review Hooman H. Rashidi MD...

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