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Unformatted text preview: Jane is an asymptomatic carrier of the dystrophin mutation and has had 3 unaffected male children. Carrier Not a Carrier Prior ½ ½ Conditional ½ 3 = 1/8 1 (odds of having three normal boys) Joint 1/16 ½ Posterior probability is 1/16 _____________ = 1/9 1/16 + 8/16 The risk that Jane’s daughter is a carrier is: Carrier Not a Carrier Prior 1/18 (1/9 x ½ ) 17/18 [1  1/18] Conditional 1/2 1 (odds of having one normal boy) Joint 1/36 17/18 Posterior probability is 1/36 ____________ = 1/35 1/36 + 34/36 The probability that she will pass on the mutation is ½ and the probability that the child will be male is ½ so the probability she will have a son affected with DMD is 1/35 x ½ x ½ = 1/140 ....
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.
 Spring '11
 staff

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