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Cancer Causing Genes Review

Cancer Causing Genes Review - Protooncogeneor Gene...

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Gene Normal Function of Gene Product MLH1, MSH2 Mismatch Repair of DNA Tumor Suppressor  ATM Tumor Suppressor  XP Tumor Suppressor  p53 Tumor Suppressor  BRCA 1,2 dsDNA repair by homologous recombination Tumor Suppressor  Rb Tumor Suppressor  APC Tumor Suppressor  HER2 Growth-Factor Receptor Protooncogene Bcl-2 Anti-apoptotic factor Protooncogene VEGF/R Protooncogene EGF/R Protooncogene Bcr-Abl "Philadelphia Chromosome" Protooncogene Protooncogene or  Tumor Suppressor? Recognize DNA damage, signal for help (activated by  dsDNA breaks), activates p53 Repairs DNA damage from UV radiation (Nucleotide  Excision Repair) a transcrption factor known as the "guardian of the  geneome", master regulator of the G1/S phase  damage checkpoint, activates p21 (a CKI) Master brake on cell cycle: binds and inhibits E2F (a  transcription factor),  Cytoplasmic protein, involved in Wnt signaling (cell  growth)
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