DNA Damage and Repair Review

DNA Damage and Repair Review - DNA Damage Source Of Damage...

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DNA Damage Source Of Damage 1. mismatch 3. chemical damage: nitrous acid oxidizing c. alkylation (ex- MeG) akylating UV radiation b. Platinum adduct on G Cisplatin a. ss break Errors of Polymerase delta/ epsilon: misincorporation (wrong base) 2. single stranded DNA loop Pol delta or epsilon "slips" across repeats a. deamination (examples: C-> U or A-> Hypoxanthine) b. oxidation (T-Thymine Glycol) 4. abnormal covalent bonds between: a. nucleotides (ex- thymine dimers) 5. Broken Phosphodiester Bonds: ionizing radiation or loss of nucleotide
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b. ss Gap (see gaps explanation above) c. ds break ionizing radiation
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substitution specifically (not addition or deletion) insertion or deletion substitution either substitution or single stranded DNA gaps either substitution or single stranded DNA gaps ss break becomes a ds break Consequence of DNA Replication Without Repair ssDNA gap in the complementary strand because the polymerase stalls at the dimer and does not synthesize that part of the sequence ssDNA gap (same reasoning as above with the polymerase) or replication stops
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(see gaps explanation above) DNA unable to be replicated
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What does it recognize? 1. Mismatch Repair
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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DNA Damage and Repair Review - DNA Damage Source Of Damage...

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