Lecture 6 (DNA Chromo Structure)

Lecture 6 (DNA Chromo Structure) - Foundations Lecture 6...

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Unformatted text preview: Foundations Lecture 6 9-9-10 (Week 1) DNA & Chromosome Structure Learning Objectives Recognize that the nucleus is a highly organized compartment that carries out a variety of complex cellular functions List the components of nucleic acids (base, sugar, and phosphate) and identify purine and pyrimidine bases and deoxyribose and ribose sugars of DNA and of RNA on the basis of their molecular structure Components of Nucleic Acid- Composed of 3: o (1) Sugar o (2) Base o (3) Phosphate- Nucleotide = Nucleic Acid ( synonymous ) - Differentiating with nucleotide triphosphate (NTP) = base + sugar + PPP (3 phosphates vs. 1 for nucleic acid) Purines vs. Pyrmidines Purines: 2 C/N rings- (1) Adenine- (2) Guanine Pyrimidines: 1 C/N ring (Pneumonic = CUT smaller ring)- (1) Cytosine- (2) Uracil- (3) Thymine 1 Foundations Lecture 6 9-9-10 (Week 1) The Sugars Ribose (RNA) & Deoxyribose (DNA)- Differences RNA Usually ss DNA Usually ds Phosphate (same) PO 4-2 PO 4-2 Sugar Ribose Deoxyribose Bases Uracil* Thymine* 2 Foundations Lecture 6 9-9-10 (Week 1) Describe the structure of polynucleotides of DNA and of RNA, including their single-stranded or double-stranded nature, their 5 to 3 orientation, and the hydrogen-bonding and pairing of specific bases in double-stranded molecules Polynucleotides Physical Structure- Connected at 3 hydroxyl and 5 phosphate phosphodiester bond- The Double Helix o 10.3 bps/turn o 3.4 nm/turn o .34 nm/bp o 2 nm wide o Clockwise/right-handed turn 3 Foundations Lecture 6 9-9-10 (Week 1) o Anti-parallel Chargaffs Rules 1. Base composition varies between species 2. DNA from different tissues of same species has the same composition 3. Base composition does not change as a function of age, nutrition, environment 4. Regardless of species, A always pairs with T (A=T), G with C (G=C)...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 6 (DNA Chromo Structure) - Foundations Lecture 6...

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