Lecture 18 Secretory Pathway

Lecture 18 Secretory Pathway - Describe the roles of the...

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Unformatted text preview: Describe the roles of the rough ER in protein modification, protein folding, and quality control of transported proteins Describe the roles of the smooth ER in lipid biosynthesis, steroid hormone synthesis, detoxification, and Ca ++ storage Recognize that improperly folded proteins are retrotranslocated from the lumen of the ER to the cytosol and ultimately degraded by proteasomes Describe how an accumulation of unfolded protein in the ER leads to an initial homeostatic transcriptional response Sketch the biosynthetic/secretory pathways of protein traffic, mapping the movement of proteins to the endoplasmic reticulum, Golgi apparatus, secretory vesicles, and the plasma membrane Vocab: ER associated degradation (ERAD), unfolded protein response (UPR), retrotranslocation, quality control, regulated secretory pathway, constitutive secretory pathway, exocytosis, mannose-6-phosphate (M6P) sorting signal, M6P receptor, clathrin, COP, Tether, RabGTPase, Snare Outline: Secretory pathway overview Protein modifications in the ER Protein Folding: ER quality control ER associated protein degradation (ERAD) and the unfolded protein response (UPR) Structure and functions of the Golgi complex Golgi to cell surface traffic: Regulated vs constitutive secretion Protein traffic from golgi to endosomes and lysosomes Vesicles budding and fusion The secretory pathway:- Vesicular transport from ER Golgi cell membrane o This include secretory protein, membrane protein, lysosomal o ER is the first step o- Two types of ER with distinctive functions o Continuity between rough and smooth ER o The ribosome are attached to the ER o Main functions of the smooth ER Lipid biosynthesis (cholesterol, fatty acids, phospholipids) Steroid hormone synthesis Detoxification of water insoluble drugs (e.g. Phenobarbital by cytochrome p450 in liver) Ca+2 storage (sarcoplasmic reticulum in muscle) o The champion of protein secretion pancreatic acinar cell specialization for protein secretion o Rough ER from exocrine pancreas The polyribosome swirls actively translating enzyme Describe the roles of the rough ER in protein m odification, protein folding, a nd quality control of transported proteins Describe the roles of the s mooth ER in lipid biosynthesis, steroid hormone synth esis, d etoxification, and Ca ++ storage Recognize that improperly folded proteins are retrotranslocated from the lumen of the ER to the cytosol and ultimately degraded by proteasomes Describe how an accumulation of unfolded protein in the ER leads to an initial homeostatic transcriptional response Vocab: ER associated degradation (ERAD), unfolded protein response (UPR), retrotranslocation, quality control, regulated secretory pathway, constitutive secretory pathway, exocytosis, mannose-6-phosphate (M6P) sorting signal, M6P receptor, clathrin, COP, Tether, RabGTPase, Snare Outline: Secretory pathway overview Protein modifications in the ER Protein Folding: ER quality control...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 18 Secretory Pathway - Describe the roles of the...

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