Lecture 21 Endocytosis

Lecture 21 Endocytosis - Sketch endocytic pathways for...

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Unformatted text preview: Sketch endocytic pathways for uptake of essential nutrients (iron, LDL), hormones, and growth factors from outside the cell Describe the three basic mechanisms by which cells internalize proteins, large particles, and organelles (endocytosis, phagocytosis, and autophagy) Name at least three important nutrients that are internalized by receptor mediated endocydosis (LDL, via the LDL receptor; Iron, via transferrin; Epidermal Growth Factor, via the EGF receptor) and describe their intracellular fate Name viruses that enter the cell via endocytosis (influenza and rabies); bacterial toxins that are taken up by endocytosis (Diphtheria, Botulinus, and Tetanus toxins); and toxins that gain access to the secretory pathway by endocytosis after uptake into endosomes (Cholera, Shiga, and Ricin) Give four examples of strategies used by bacteria to circumvent destruction by lysosomal digestion (Inhibition of fusion of lysosomes with the phagocytic vacuole ( Toxoplasma, Chlamydia, Mycobacterium ); Protective layer to prevent lysosomal degradation ( Mycobacterium lepraemurium ); Neutralization of the lysosomal enzymes ( Leishmania ); Escape from the vacuole into the cytoplasm ( Listeria monocytogenes, Trypanosoma cruzi ) Vocab Endocytosis, phagocytosis, autophagy, receptor-mediated endocytosis, low density lipoprotein (LDL) receptor, transferring receptor, transferring, epidermal growth factor (EGF) receptor, EGF, tyrosine sorting signal, clathrin coated vesicles, transcytosis Outline- The endosome-lysosome system- Receptor mediated endocytosis o LDL receptor: Uptake of LDL o Transferrin Receptor: Uptake of Iron o Growth Factor Receptors: Uptake of EGF o Viral and toxin entry o Tyrosine sorting signal: discovery in patients o With familial hypercholesterolemia- Coat proteins of clathrin coated vesciles- Transcytosis: transcellular transport- Phagocytosis: neutrophils and machophages- Materials taken up by endocytosis, phagocytosis, and autophaghy are degraded in lysosomes o Autophagy: process of taking stuff from inside the cell to dispose old warn out organelles (self-eating) o Micromolecule, protein, other particles are taken up (taken into endosomal systems, degraded in lysosomes) o- Turnover of mitochondria and peroxisomes by autophagy o Mitochondria llives for 10 days- Types of endocytic carrier vesicles o *add notes from slides o Sketch endocytic pathways for uptake of essential nutrients (iron, LDL), hormones, and growth factors from outside the cell Describe the three basic mechanisms by which cells internalize proteins, large particles, and organelles (endocytosis, phagocytosis, and autophagy) Name at least three important nutrients that are internalized by receptor mediated endocydosis (LDL, via the LDL receptor; Iron, via transferrin; Epidermal Growth Factor, via the EGF receptor) and describe their intracellular fate Name viruses that enter the cell via endocytosis (influenza and rabies); bacterial toxins that are taken up by endocytosis (Diphtheria, Botulinus,...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 21 Endocytosis - Sketch endocytic pathways for...

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