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Unformatted text preview: these signals lead to cellular responses (e.g., contraction, secretion, migration, transcription). Explain how knowing which G-protein is activated would help you predict the cellular response an agonist or drug would elicit and recognize why the response would vary depending on cell type (smooth muscle, cardiac muscle, gland). Vocab: G-protein coupled receptor (GPCR), Heterotrimeric G-protein (alpha, beta, gamma subunits), agonist/ligand, receptor subtypes/selectivity, guanine nucleotide exchange factor (GEF), effector, second messenger, adenylyl cyclase/cAMP, phopholipase C/InsP3/Ca++, RhoA, Contractility, contraction (constriction, dilation), secretion, hyperpolarization, side-effect/off target effeect...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.
- Spring '11