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Lecture 22 Cell Signaling 1

Lecture 22 Cell Signaling 1 - these signals lead to...

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Recognize the importance of cell-cell signaling in regulating acute and chronic physiological and pathophysiological responses Identify and contrast the three main types of surface receptors: ion channel-linked, G protein-linked, and enzyme-linked. Recognize that many classes of endogenous agonists and a significant fraction of drugs exert their effects by interacting with G protein-coupled receptors (GPCRs). Describe the properties of G protein- coupled receptors (GPCRs) and of heterotrimeric G-proteins and understand the mechanisms of their activation and deactivation. Define the effectors that are directly regulated by GPCRs through specific G-proteins, the important second messengers, kinases, and signaling pathways that are activated and how
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Unformatted text preview: these signals lead to cellular responses (e.g., contraction, secretion, migration, transcription). Explain how knowing which G-protein is activated would help you predict the cellular response an agonist or drug would elicit and recognize why the response would vary depending on cell type (smooth muscle, cardiac muscle, gland). Vocab: G-protein coupled receptor (GPCR), Heterotrimeric G-protein (alpha, beta, gamma subunits), agonist/ligand, receptor subtypes/selectivity, guanine nucleotide exchange factor (GEF), effector, second messenger, adenylyl cyclase/cAMP, phopholipase C/InsP3/Ca++, RhoA, Contractility, contraction (constriction, dilation), secretion, hyperpolarization, side-effect/off target effeect...
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