Lecture 24 The Cytoskeleton - Cell Structure and Movement

Lecture 24 The Cytoskeleton - Cell Structure and Movement -...

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Unformatted text preview: Explain how cell shape, organization, and motility are orchestrated by a dynamic set of protein polymers collectively termed the cytoskeleton Outline the properties of each of the three major cytoskeletal filament systems, and explain how their properties allow them to mediate their cellular functions DeFne the terms intravasation and extravasation and explain how they relate to cancer metastasis Explain the two major functions of motor proteins: (1) cargo transport, and (2) Flament transport Explain how the chemotherapeutic agents paclitaxel and the vinca alkaloids affect microtubule polymerization Describe the role of kinesin and dynein in organelle transport Appreciate that defects in ciliary structure and motility are associated with a collection of disorders, termed ciliopathies Vocab cytoskeleton, actin, microtubule, intermediate filaments, myosin, dynein, kinesin, microvilli, intravasation, extravasation, nucleation, keratin, dynamic instability, primary cilium Outline: A) Actin cytoskeleton 1) Roles of the actin cytoskeleton Actin assembly 2) Myosins 3) Crawling cells B) Intermediate filaments 1) Intermediate filament structure 2) An example: Keratins C) Microtubule cytoskeleton 1) Microtubule assembly 2) Drugs alter microtubule assembly 3) Microtubule motor proteins 4) Cilia- The cytoskeleton o Is the internal skeleton of the cell o Provides structure to the cell o Serves as a system of tracks o Whats is it? .. microtubules, actin filaments, DNA- 3 cytoskeleton filament systems o o ____ _____ increasing diameter- Actin cytoskeleton: Roles of the actin cytoskeleton in cells o Actin cooperates with myosin II to form contractile structures o Muscle The motor pulls the actin to give the construction o Contractile Ring Like the dicytostelium amoeba o Actin polymerization changes cell shape Platelet dynamics Platelet activation is accompanied by massive polymerization of new actin filaments Filaments are cross-linked into a contractile structure that attaches to the blood clot To form structure that adheres to the blood Explain how cell shape, organization, and motility are orchestrated by a dynamic set of protein polymers collectively termed the cytoskeleton Outline the properties of each of the three major cytoskeletal filament systems, and explain how their properties allow them to mediate their cellular functions De ne the terms intravasation and extravasation and explain how f they relate to cancer metastasis Explain the two major functions of motor proteins: (1) cargo transport, and (2) lament transport f Explain how the chemotherapeutic agents paclitaxel and the vinca alkaloids affect microtubule polymerization Describe the role of kinesin and dynein in organelle transport Appreciate that defects in ciliary structure and motility are associated with a collection of disorders, termed ciliopathies Vocab cytoskeleton, actin, microtubule, intermediate filaments, myosin, dynein, kinesin, microvilli, intravasation, extravasation, nucleation,...
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Lecture 24 The Cytoskeleton - Cell Structure and Movement -...

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