Lecture 26 Control of the Cell Cycle

Lecture 26 Control of the Cell Cycle - Describe how...

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Unformatted text preview: Describe how defective control of the cell cycle can contribute to cancer Name and describe the four phases of the cell cycle, and explain why their progress must be tightly regulated Describe the role of cyclin dependent kinases (CDKs) in regulating the initiation of steps in the cell cycle Describe the mechanisms of control of CDKs, including binding to cyclins, phosphorylation, and inhibitor binding Explain how an explosive increase of mitotic CDK activity and S-phase CDK lead directly to the events of mitosis and S phase, respectively Explain the role of cell cycle checkpoints in insuring the fidelity of the cell cycle Explain how loss of heterozygosity of a mutant gene encoding a checkpoint protein can lead to a greatly elevated risk of cancer Vocab Mitogen, G , G 1 , S, G 2 , M, Interphase, Cyclin Dependent Kinase (CDK), Cyclin, Positive Feedback, Checkpoint, CDK Inhibitor (CKI), p53, Li Fraumeni Syndrome, Loss of Heterozygosity (LOH) Outline: Stages of the Cell Cycle Cell Cycle Control System- Cyclin Dependent Kinases (CDKs) control timing- Checkpoints ensure integrity Loss of Heterozygosity and Cancer - o Details of the cell is not important o Overview: Mitogens activate receptors Receptors transducer signals Signals activate cell cycle machinery Cell goes through cell cycle- Control of the cell cycle: Stages of the cell cycle o G1 = GAP 1 Follows cell division and mitosis, but it occurs before DNA synthesis Beginning, resting phase of cell cycle G(0) is a sunphase of G1; cells can remain there indefinitely (e.g. neurons) Cell growth without cell division o S= DNA synthesis Entire genome is replicated exactly once Must be very precise and accurate o G2=Gap2; it follows DNA synthesis and precedes mitosis DNA repair Additional cell growth o M=Mitosis; replicated chromosomes are segregated precisely to each pole Nuclear membrane breaks down; chromosomes condense Chromosomes attach to the mitotic spindle Chromosomes move to the metaphase plate Chromosomes are separated from one another Describe how defective control of the cell cycle can contribute to cancer Name and describe the four phases of the cell cycle, and explain why their progress must be tightly regulated Describe the role of cyclin dependent kinases (CDKs) in regulating the initiation of steps in the cell cycle Describe the mechanisms of control of CDKs, including binding to cyclins, phosphorylation, and inhibitor binding Explain how an explosive increase of mitotic CDK activity and S-phase CDK lead directly to the events of mitosis and S phase, respectively Explain the role of cell cycle checkpoints in insuring the fidelity of the cell cycle Explain how loss of heterozygosity of...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 26 Control of the Cell Cycle - Describe how...

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