Lecture 27 Cell Division - Mitosis and Meiosis

Lecture 27 Cell Division - Mitosis and Meiosis - Explain...

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Explain why chromosome segregation must occur with very high fidelity Describe the roles of cohesion and condensation in preparing the genome for segregation Describe the major functions and morphological features of each stage of mitosis: Prophase, Prometaphase, Metaphase, Anaphase, Telophase, Cytokinesis Describe the basic features and regulatory function of the Spindle Checkpoint Compare the segregation and morphology of chromosomes in Meiosis I, Meiosis II, and Mitosis Explain why anti-mitotic drugs can be appropriate choices as anti-cancer drugs Vocab Spindle, Kinetochore, Centrosome, Cohesin, Condensin, Nuclear Envelope Breakdown, Lamin, , Prophase, Prometaphase, Metaphase, Anaphase, Telophase, Cytokinesis, Gamete, Chiasma, Recombination, Homologous Chromosomes, Down Syndrome Outline A)Preparing the Genome for Mitosis B)Stages of Mitosis & Mitotic Mechanisms C)Meiosis - Cell division is the key to life - Preparing the genome for mitosis o Mitosis generates two daughter cells following DNA replication M phase – two duplicate of genome either side and then the mother cell splits to form daughter cells o Two acts of mitosis Chromosome segregation 2 sister chromatid where 1 sister goes to one side and one to the other side Cytokinesis (actin myosin) fidelity is of central importance o The cargo of mitosis: the duplicated genome packaged into chromosomes Chromatid – ½ of the chromosome; held together until mitosis Kinetochore – make sure segregation goes correctly 46 cargos – 23 pairs o Chromosome segregation in human cells Mitosis in human cells: chromosome are aligned at a very exact position and then is pulled o Mitotic defects and aneuploidy in Tumor cells (> 100 years ago) Tumors continuely make mistakes through more cell division o The genome segregation machinery accommodates dramatic variations in chromosome number An ant has the least amount o The mitotic spindle Chromosomes – precisely packaged Microtubules – build at entry of M phase Kinetochores – the linking of chromosome to microtubules Explain why chromosome segregation must occur with very high fidelity Describe the roles of cohesion and condensation in preparing the genome for segregation Describe the major functions and morphological features of each stage of mitosis: Prophase, Prometaphase, Metaphase, Anaphase, Telophase, Cytokinesis Describe the basic features and regulatory function of the Spindle Checkpoint
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Compare the segregation and  morphology of chromosomes in  Meiosis I, Meiosis II,  and Mitosis Explain why anti-mitotic drugs can  be appropriate choices as anti-cancer  drugs Vocab Spindle, Kinetochore, Centrosome,  Cohesin, Condensin, Nuclear  Envelope Breakdown, Lamin, ,  Prophase, Prometaphase, Metaphase,  Anaphase, Telophase, Cytokinesis,  Gamete, Chiasma, Recombination,  Homologous Chromosomes, Down  Syndrome Outline A)Preparing the Genome for Mitosis
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 27 Cell Division - Mitosis and Meiosis - Explain...

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