Lecture 38 - Population Genetics

Lecture 38 - Population Genetics - Enumerate the different...

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Unformatted text preview: Enumerate the different forms of - inherited and somatic DNA sequence variations Define “polymorphism”: DNA sequence variation that is frequent in the population Describe the role of random genetic drift in population differentiation and “races” Define hardy-Weinberg equilibrium and factors that create deviations from it (if the test fail – what are the factors) Exploit Bayes rule in assessing genotype carrier/frequency probabilities Vocab: Single Nucleotide Polymorphism or Variant (SNP/SNV); indel; inversion; Copy Number Variant (CNV); drift; genetic differentiation; Hardy- Weinberg equilibrium; consanguinity; Bayes rule Outline: Population Genetics 1. Forms of DNA Sequence Variation 2. Polymorphism: Example Resources for Population Genetics 3. Population Differentiation 1. Lewontin’s study 2. Modern Population Genetics 4. Random Drift, Population Differentiation, and Evolution 1. Sewall Wright and Genetic Drift 2. Random/Stochastic Processes in Phenotypic Emergence 5. Hardy-Weinberg Equilibrium (HWE) 1. Calculation 2. Deviations from HWE 6. Bayes Rule and Conditional Genotype Probabilities Forms of DNA Sequence Variation- Most abundant is the single nucleotide variant- Insertion/deletion variant- Inversion – the entire sequence is inverted- Copy number variant – entire stretches of genome (LARGE chunk) are repeated through the genome o i.e. it can cover the functional copy of a gene- how likely is it to arise - females – meiosis done very early in life – a pool of eggs that is there through out life - males – sperm is being generating throughout life o new mutation frequency is probably contributed by males more than females (simply because it can occur throughout life and not just there already) Enumerate the different forms of - inherited and somatic DNA sequence variations Define “polymorphism”: DNA sequence variation that is frequent in the population Describe the role of random genetic drift in population differentiation and “races” Define hardy-Weinberg equilibrium and factors that create deviations from it (if the test fail – what are the factors) Exploit Bayes rule in assessing genotype carrier/frequency probabilities Vocab: Single Nucleotide Polymorphism or Variant (SNP/SNV); indel; inversion; Copy Number Variant (CNV); drift; genetic differentiation; Hardy- Weinberg equilibrium; consanguinity; Bayes rule Outline: Population Genetics 7. Forms of DNA Sequence Variation 8. Polymorphism: Example Resources for Population Genetics 9. Population Differentiation 1. Lewontin’s study 2. Modern Population Genetics 10. Random Drift, Population Differentiation, and Evolution 1. Sewall Wright and Genetic Drift 2. Random/Stochastic Processes in Phenotypic Emergence 11. Hardy-Weinberg Equilibrium (HWE) 1. Calculation 2. Deviations from HWE 12. Bayes Rule and Conditional Genotype Probabilities- Population Genetics -- Polymorphism: Example Resources for Population Genetics o The HapMap Database ( www.hapmap.org ) Hap – a stretch of nucleotide that is transmitted and pass...
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Lecture 38 - Population Genetics - Enumerate the different...

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