Quiz Week 03

Quiz Week 03 - Foundations- Week 3 Formative Quiz for PS2s...

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Question 1 of 18 1. The diagram below depicts a portion of a cell membrane and organelles involved in endocytosis. Letters indicate cell locations or organelles, while arrows represent the processes leading from one labeled location to the next. In liver cells taking up low density lipoprotein (LDL), what letter indicates the location at which the greatest fraction of LDL will be released from LDL receptors? A B C D E 0 out of 1 The Correct Answer is: B Question 2 of 18 2. Iron is taken up into liver cells as ferrotransferrin (iron bound to apotransferrin), which binds to transferrin receptors on the liver cell. Which of the following best describes the cellular fates of the transferrin receptor, the apotransferrin protein and the iron? A. Ferrotransferrin is released from the transferrin receptor in the endosome, and ferrotransferrin is delivered to the lysosome. B. Ferrotransferrin remains bound to the transferrin receptor, and the complex is delivered to the lysosome. C. Iron and apotransferrin are released in the endosome, and apotransferrin is delivered to the lysosome D. Iron is released from apotransferrin in the endosome, and is transported into the cytosol. 0 out of 1 The Correct Answer is: D. Iron is released from apotransferrin in the endosome, and is transported into the cytosol. Question 3 of 18 3. Activation of EGF receptors recruits multiple proteins to the EGF receptor and activates multiple signaling pathways, including which of the following? A. Binding of MAP kinase to the EGF receptor activates signaling that stimulates protein synthesis. B. Binding of PI3-kinase to the EGF receptor activates signaling leading to mitosis. C. Binding of PI3-kinase to the EGF receptor activates signaling that stimulates cell survival. D. Binding of Ras to the EGF receptor activates signaling leading to cell growth. 1 out of 1 The Correct Answer is: C. Binding of PI3-kinase to the EGF receptor activates signaling that stimulates cell survival. Question 4 of 18 4. During the immune response to a cut infected with bacteria, the bacteria stimulate macrophages to secrete a cytokine called TNF Many cells express TNF receptors, including macrophages and endothelial cells of capillaries. TNF can further activate local macrophages, upregulate adhesion proteins on local endothelial cells, and travel through the blood to modify a "set-point" in the brain to cause a fever. Which of the following most accurately describes the endocrine, paracrine and autocrine actions of TNF ? A. TNF acts in an autocrine manner to activate capillaries adjacent to the macrophage that secreted it. B. TNF
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This note was uploaded on 09/14/2011 for the course PHARM HB taught by Professor Staff during the Spring '11 term at UCSD.

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Quiz Week 03 - Foundations- Week 3 Formative Quiz for PS2s...

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