DNA Replication and Mutations - DNA Replication &...

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1. DNA replication Emphasis on eukaryotes Semi-conservative process Conservative all the original material from the base DNA is present in the new DNA De novo replication none of the original DNA material is present in the new copy Helicase and topoisomerase Helicase enzyme that unwinds the DNA molecule into 2 separate strands (seperates on multiple replicative regions) Topoisomerase acts as glue by binding DNA in replicative regions to keep from wrapping back on its own DNA Polymerase takes a single strand of DNA and connects it with another 2. DNA Replication and Mutations DNA polymerase produces errors at points within a DNA molecule Beyond copying, DNA polymerase also proofreads for these errors ands fixes them when they are found After being proofread (see drawing), the errors that still make it through are called the net error rate, the total rate of missed errors Prokaryotes: net error rate = 1/1x10^6 nucleotides Eukaryotes: net error rate = 1/1x10^9 nucleotides
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This note was uploaded on 09/14/2011 for the course BIO 1001 taught by Professor Staff during the Fall '08 term at Cornell University (Engineering School).

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DNA Replication and Mutations - DNA Replication &...

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