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Asthma - Asthma chronic disease that results from...

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Asthma - chronic disease that results from inflammation and narrows the airways - excess mucus - narrowing of airway - swelling - Risk Factor: environmental factors and genetics - Symptoms: coughing, wheezing, chest tightness, SOB - Causes o Allergens (dust mites, animal dander, cockroaches) o Irritants (cigarette smoke, air pollution, chemicals/dust) o Medications (ASA) o Sulfites (foods/drinks) o Upper respiratory infections (colds) o Exercise Inflammation of the airway wall Innate & adaptive immunity are involved Recruitment/activation of eosinophils, basophils, mast cells, lymphocytes (T-helper type 2,Th2) Release/production of inflammatory mediators, cytokines 1) Mast cell sensitization - Step I: exposure to antigeninduced systemic generation of antibodies via B cells and T helper cells - Step II: IgE antibody fixation on the mast cell surface - Step III: Antigen binding to IgE/FcR signaling, and secretory granule content release (degranulation) - Mast cell mediators: a. Lipid-derived mediators generated by mast cell PLA2 activation i.
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