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Unformatted text preview: Asthma- chronic disease that results from inflammation and narrows the airways- excess mucus- narrowing of airway- swelling- Risk Factor: environmental factors and genetics- Symptoms: coughing, wheezing, chest tightness, SOB- Causes o Allergens (dust mites, animal dander, cockroaches) o Irritants (cigarette smoke, air pollution, chemicals/dust) o Medications (ASA) o Sulfites (foods/drinks) o Upper respiratory infections (colds) o Exercise Inflammation of the airway wall Innate &amp; adaptive immunity are involved Recruitment/activation of eosinophils, basophils, mast cells, lymphocytes (T-helper type 2,Th2) Release/production of inflammatory mediators, cytokines 1) Mast cell sensitization- Step I: exposure to antigeninduced systemic generation of antibodies via B cells and T helper cells- Step II: IgE antibody fixation on the mast cell surface- Step III: Antigen binding to IgE/FcR signaling, and secretory granule content release (degranulation)- Mast cell mediators: a. Lipid-derived mediators generated by mast cell PLA2 activation i. Same actions as HM with slower onset and longer duration ii. LTC4/LTDr previously called ii....
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This note was uploaded on 09/14/2011 for the course PHARM pp taught by Professor Staff during the Spring '11 term at UCSD.
- Spring '11