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Drug Metabolism (Caroline)

Drug Metabolism (Caroline) - Drug Metabolism...

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Drug Metabolism Xenobiotic=foreign compound Drugs generally lipophillic to get thru membranes, but problem cuz kidneys like  water soluble things. Body has gotten around this via liver metabolism Hydrophobic compound goes to liver and is made hydrophilic when goes to  kidney Phase I o Introduce new functional group, like P450 enzymes; or, expose something  via hydrolytic reaction or reduction Phase II o Conjugate a polar group to it (sulfate, glucoronic acid, etc…) P450s In liver, kidney, lung Cannot fxn alone, need P450 reductase to deliver electrons Levels are not constant go up or down in response to exposure to  compounds, like Phenobarbital (induces P450 synthesis) Heart shaped molecule: alpha helices on 1 side, beta on other Contains a heme group Take hydrophobic molecule, introduce 1 O from O2, other O in water
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