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Drugs for Psychotic and Cognitive Disorders

Drugs for Psychotic and Cognitive Disorders - Drugs for...

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Drugs for Psychotic and Cognitive Disorders Nootroptics: to improve cognitive thinking, memory Psychosis o =Hallmark of schizophrenia o Can be psychotic behavior, like hallucinations, delusions = (+) symptoms Hallucinations: seeing something not there Delusions: false beliefs that aren’t happening, like someone is following me o (-) symptoms = social withdrawal; not feeling pleasure, general malaise. Treated better by the 2 nd generation drugs. o Chlorpromazine: 1 st antipsychotic drug (tested for anesthesia) Pt’s on whom drug being tested were mental pts, because these were subjects frequently used for drug tests People who had hallucinations/delusions, suddenly didn’t have them. Also prophylactic, preventing occurrence. # hospitalized mental pts severely decreased (by 80%) Problem = don’t decrease (-) symptoms, pts still withdrawn and apathetic. Don’t cure. Drug terminology o Antipsychotics Neurological, extra-pyramidal symptoms Want separation between neuroleptic and antipsychotic effects and 2 nd generation drugs are better at this. DA theory of schizophrenia o Amphetamine releases DA and can induce positive symptoms of psychosis o When block D2, you block positive symptoms. o All clinically effective antipsychotic drugs block the D2 receptor (not the case for D1 or any other receptor)
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Mesolimbic/cortical pathway, where we think there is hyperactivity o
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