Pharmacology of Antiarrhythmics

Pharmacology of Antiarrhythmics - o You can have a lot of...

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Pharmacology of Antiarrhythmics - Agents that aren’t usually used commonly (usually special clinics) Review normal cardiac activation and recovery - Only the his purkinje cell has the usual Phase 0-4 - Ventricle and Atrium cells has no phase 1 - Phase 0 –Na+ channels in most cardiac cells except o AV node is the only one with Ca++ - SA and AV node upsloping phase 4 diastolic APs automaticity (where they can fire on their own) - Normal ion currents and the cellular AP o o Phase 0 – Na Phase 2-3 – Ca Phase 4 – Na and K exchangers o The pacemaker – SA / AV node upward current for the Phase 4 antiarrhythmics Discuss antiAR - AR best for tachyarrhythmias o Side ffects of meds for BA preclude long term use - AR used for AR suppression or rate control
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Unformatted text preview: o You can have a lot of symptoms of fast heart can leave to HF-Device therapy is definitive treatment for bradyarrhythmia o Pace makers to controls low heart rate-Vaughn-Williams Classification o Drugs are classified major effects o Several durgs have >1 class of action Amiodaron e all 4 classes Propafenone classes IC and II o Digoxin falls outside this classification-Class I – Na+ blockers-Class II – Beta blockers-ClassIII – K+ Channel blockers-Class IV – Ca++ channel blockers Side effects of AAs: Proarrhythmia-All antiR medications also be proarrhythmia o Class I sodium channel blockers o Class III K+ channel blockers-Torsades de Pointes o Prolonged QT...
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