PPP - Cho

PPP - Cho - Cholingeric Drugs Nicotine Therapeutic Uses...

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Cholingeric Drugs Effects Therapeutic Uses Nn Ag oni sts Nicotine - Drug abuse N M An tag oni sts D-tubocurarine - Flaccid paralysis (skeletal muscle) - Reverse with Anti-AChE agents (inc. Ach) - Long duration of action (side effects – also blocks N n receptors - Analogs are used more because of fewer side effects and better PK profiles -paralysis & relaxation of SKM (anesthetic) Succinycholine - Transient fasciculations followed by flaccid paralysis (skeletal muscle) - Commonly used – rapid onset, short duration due to rapid metabolism by BuChE -paralysis & relaxation of SKM (anesthetic) N N Agoni sts Nicotine - Drug abuse N M rec ept ors Trimethaphan Mecamylamine
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Drugs Effects Therapeutic Uses An ti- Ch E ag ent s Noncovalent - Edrophonium - Donepezil - Galantamine Edrophonium : - Reversal of neuromuscular blockage caused by competitive neuromuscular blocking agents (not depolarizing agents) Speeds recovery for paralysis post surgery Donepezil & Galantamine - Alzheimer’s disease Degeneration of certain
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PPP - Cho - Cholingeric Drugs Nicotine Therapeutic Uses...

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