PPP - Drug List Winter Final

PPP - Drug List Winter Final - Drug MOA Indication -...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Drug MOA Indication Side Effects Diazepam (BDZs) - GABA(a) receptor inhibitor (allosterically) - Spasmolytic due to CNS and muscle/joint trauma - Spasmolytic due to local tissue injury, muscle sprains NOT CNS - SKM relaxant - Essential tremor (postural or action) Sedative effects When used for essential tremor – withdrawal syndrome with exacerbation of tremor Lorazepam Alprazolam (BDZs) - CINV - PONV Sedative Anxiolytic Amnesic effects Baclofen - GABA(b) receptor antagonist - Spasticity due to CNS - Amyotrophic lateral sclerosis (ALS) – spasticity symptoms SKM weakness Less sedative Tizanidine - Alpha2 agonists - Spasticity due to CNS - Amyotrophic lateral sclerosis (ALS) – spasiticity symptoms Drowsiness Dry mouth Dantrolene - Blocks release of Ca++ from SR at RyR1 - Acts directly on the skeletal muscle - Spasticity due to CNS disorders - Neuroleptic malignant syndrome (EPS, severe PD, high fever symptoms) - Maligant hyperthermia (volatile anesthetic+succinylcholine, muscle rigidity, high fever) SKM weakness Hepatotoxicity (rare) Cyclobenzaprine Carisoprodol * (metabolite potential for abuse) Clorzoxazone - Poorly understood - No more effective than NSAIDs - Spasmolytic due to local tissue injury, muscle sprains NOT CNS - SKM relaxant Drowsiness Propanolol - Some Beta 2 - Essential tremor (postural or action)
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 7

PPP - Drug List Winter Final - Drug MOA Indication -...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online