PPP - Drug List Winter Final

PPP - Drug List Winter Final - Drug MOA Indication...

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Drug MOA Indication Side Effects Diazepam (BDZs) - GABA(a) receptor inhibitor (allosterically) - Spasmolytic due to CNS and muscle/joint trauma - Spasmolytic due to local tissue injury, muscle sprains NOT CNS - SKM relaxant - Essential tremor (postural or action) Sedative effects When used for essential tremor – withdrawal syndrome with exacerbation of tremor Lorazepam Alprazolam (BDZs) - CINV - PONV Sedative Anxiolytic Amnesic effects Baclofen - GABA(b) receptor antagonist - Spasticity due to CNS - Amyotrophic lateral sclerosis (ALS) – spasticity symptoms SKM weakness Less sedative Tizanidine - Alpha2 agonists - Spasticity due to CNS - Amyotrophic lateral sclerosis (ALS) – spasiticity symptoms Drowsiness Dry mouth Dantrolene - Blocks release of Ca++ from SR at RyR1 - Acts directly on the skeletal muscle - Spasticity due to CNS disorders - Neuroleptic malignant syndrome (EPS, severe PD, high fever symptoms) - Maligant hyperthermia (volatile anesthetic+succinylcholine, muscle rigidity, high fever) SKM weakness Hepatotoxicity (rare) Cyclobenzaprine Carisoprodol * (metabolite potential for abuse) Clorzoxazone - Poorly understood - No more effective than NSAIDs - Spasmolytic due to local tissue injury, muscle sprains NOT CNS - SKM relaxant Drowsiness Propanolol - Some Beta 2 - Essential tremor (postural or action)
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