PPP -- COPD Asthma

PPP -- COPD Asthma - PPP- Asthma & COPD...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: PPP- Asthma & COPD Pulmonary Artery Hypertension Asthma (obstruction) COPD (obstruction) Elevated PA pressure Vascular proliferation Remodeling of small pulmonary arteries Progressive increase in pulmonary vascular resistance Right heart failure and death  Interplay of pulmonary vascular smooth muscle cells and pulmonary vascular endothelium Imbalance between mediators of vasoconstriction and vasodilation TREATMENT:  Calcium channel blockers Nifedipine: Generally poorly effective  Prostacyclin Intravenous epoprosenol [e.g. FLOLAN] Iloprost [VENTAVIS], protacyclin analog, inhalation 6-9 times/day  Endothelin Receptor Antagonists Blocks ET-1 a potent pulmonary vasoconstrictor A chronic inflammatory disease of the airways A chronic inflammatory disease of the respiratory tract Mast cell activation Eosinophil infiltration Bronchoconstriction Histamine Leukotrine D4 Prostoglandin D2 Predominance of neutrophils, macrophages and cytotoxic T-lymphocytes Airway hyper-responsiveness Increased mucus secreting cells and mucus Inflammation responsive to glucocorticoids (mostly) Small airway narrowing and fibrosis (chronic obstructive bronchiloitis) Destruction of alveolar walls (emphysema) Inflammation unresponsive to glucocorticoids (mostly) Often early disease onset (childhood) Often not progressive Strongly smoking related Progressive Bosentan [TRACLEER]...
View Full Document

Page1 / 7

PPP -- COPD Asthma - PPP- Asthma & COPD...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online