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PPP Adrenergic Drug List

PPP Adrenergic Drug List - PPP October 2010 Drug List...

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PPP, October, 2010 Drug List - Adrenergic Pharmacology Drugs affecting NE synthesis, storage, exocytosis, reuptake, and metabolism Inhibition of tyrosine hydroxylase: α-methyltyrosine Inhibition of amine transport into storage vesicles via VMAT-2: reserpine Displacement of NE from storage vesicles (indirect sympathomimetics): amphetamine , ephedrine (also a weak α and β agonist) Inhibition of NET: cocaine , tricyclic antidepressants Inhibition of NE metabolism: MAO inhibitors ( selegiline, pargyline ), COMT inhibitors ( tolcapone, entacapone ) α Receptors Agonists α 1 -selective: phenylephrine [NEO-SYNEPHRINE, SUDAFED PE], methoxamine α 2 -selective: α-methyldopa [ALDOMET], clonidine [CATAPRES] Antagonists Non-selective: phentolamine, phenoxybenzamine α 1 -selective: prazosin [MINIPRESS] α 2 -selective: yohimbine β Receptors Agonists Non-selective: isoproterenol (isopropyl NE) [ISUPREL] β 1 -selective: dobutamine [DOBUTREX] β 2 -selective: albuterol [PROVENTIL, VENTOLIN] Antagonists
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PPP Adrenergic Drug List - PPP October 2010 Drug List...

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